CRISPRscreen
One of the coolest emerging genetic technologies is CRISPR, which allows for unprecedented control over modifying genomes. We took advantage of CRISPR's high rate of mutagenesis to perform the first in vivo reverse genetic screen in a vertebrate. We screened for electrical synapse defects but also found that the approach was applicable to many different developmental processes. The method will greatly facilitate the interrogation of gene function in vertebrates.
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RNAmapper

One of the main goals in lab is to be able to quickly interrogate gene function in vivo in a vertebrate system. As zebrafish geneticists we love to be able to make mutations in genes and then assess the phenotypic outcome. However, classic forward genetic approaches, in which random mutations are generated in the genome, are notoriously slow at the stage of identifying the mutated gene. Its akin to finding a needle in a haystack. To speed the process we developed a next generation sequencing method to quickly map and identify mutated genes.
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