The Big Picture

Miller lab science
How does the brain wire together? The human brain is incredibly complex, containing more connections between neurons than the Milky Way galaxy has stars! The brain is wired into stereotyped neural circuits, which underlie sensation, information processing, movement, and even consciousness. Disruption of wiring during development has been linked to many neurodevelopmental disorders, including autism.

So how do the neurons of the brain connect and wire up into circuits? We use zebrafish as a relatively simple model system and use genetics, biochemistry, cell biology, circuit function, and behavior, to understand how the brain creates functioning neural networks. Moreover, we aim to use the system to examine how to rewire the brain in models of neurodevelopmental disease or after injury.

Check out what the lab is up to in the links above.
If you are interested in a position check our our available positions.
  • 8/19 - First Atlas paper out at bioRxiv! Dylan's manuscript describes our draft Atlas of zebrafish development from 1-5 days post fertilization and highlights the power of this work to help the entire community. Further information on using this resource can be found here.
  • 6/19 - Brennan Miller joins the lab! He will be working with Jen on electrical synapse scaffolds. Welcome!
  • 4/19 - R24 awarded for the single-cell RNA-seq Atlas, thanks NIH Office of the Director! This is a collaborative grant between the Postlethwait, Kimmel, Westerfield, and Miller labs.
  • 4/19 - Ali Eggling joins the lab! She will be working with Anne. Welcome!
  • 2/19 - Newest and youngest lab member, Madora Grace Miller. Born happy and healthy, and just in time for the snow storm!
  • 1/19 - Anne Martin joins the lab as a postdoc! She comes from a successful thesis at the University of Utah with Megan Williams. She will be working on E/I balance with a new angle - how do electrical synapses contribute to synaptic homeostasis? Can't wait to find out! Welcome Anne! 
  • 1/19 - R01 awarded for the electrical synapse work, thanks NINDS!
  • 08/18 - Another quarterly update. Welcome to the lab Rachel! Congrats to Audrey and Anisha for going off to grad school and the NIH PostBac program, respectively!!! Good luck. Soon an update of the lab website to encompass the many new directions the lab is going - stay tuned.
  • 03/18 - Important work from the Pew about discrimination in STEM. Critical to think about how this impacts all of us, and what we can do to improve.
  • 02/18 - I've been lax about updating of late because we've just been too busy with cool stuff. The last few months we've had tons of postable good stuff happening. Our first paper is out, nice work Audrey! She even got a cool preview of her work written up here. Audrey is just so cool that now she is off on her interviews for grad school, and will have the pick of the country, congrats Audrey! We will know soon where she is going to end up. Anisha just got a post-bac job at the NIH, hell yeah! And Rachel came and did a great rotation and gave a great talk on her work Fall term. We've been busy, and things are looking good. Stay tuned for a major update to the website and our directions -  we have lots of cool projects and new innovative things going on, and we've outgrown our starter website, so we will upgrade and highlight all the cool science that has been happening of late. 
  • 08/17 - Mine gives a great poster from her work, well done!
  • 07/17 - Cool single-cell RNA-seq stuff from Dylan!
  • 06/17 - Mine joins the lab for the summer, welcome!
  • 06/17 - Abbey gets funded by the DTG!!! Abbey, you rock!
  • 06/17 - We have our own lab! 314 Huestis, visit us!
  • 05/17 - Abbey official joins the lab as our first grad student! Woohoo!
  • 05/17 - Connexin asymmetry paper published in eLife! 
  • 04/17 - Anisha wins the Bess Templeton Cristman Award! Anisha is winning all the things, congrats!
  • 04/17 - Anisha gets a VPRI summer grant for her work, winner!
  • 04/17 - Abbey joins for a rotation, yeah!
  • 03/17 - Anisha wins a mini-grant for her work on coiling fish! YES!!!
  • 02/17 - Dylan started, alright!!!
  • 02/17 - Laura joins as a new undergrad, welcome!
  • 01/17 - 3D modeling of lab - its going to be nice!
  • 01/17 - Lab demo has started, check it out.
  • 01/17 - Welcome Denver and Alex for rotations!
  • 12/16 - Miller lab turns one year old!
  • 11/16 - Jen sent off a great grant - good luck!
  • 09/16 - Austin and Emily join for rotations, welcome!
  • 07/16 - Dylan joins the lab! He will start up in early 2017.
  • 06/16 - Adam wins Chi-Bin Chien Award!
  • 05/16 - Audrey found that Tjp1b is required exclusively postsynaptically. First official lab paper here we come!
  • 04/16 - Anisha finishes the first figure for the first paper from the lab!!! We can do things!
  • 03/16 - Jen joins the lab!!!
  • 01/16 - New lab photos, looking good.
  • 01/16 - Miller lab warming party - champagne and beer and scotch!
  • 01/16 - The lab can now do PCR! Audrey's proof is here!
  • 01/16 - Anisha joins the lab! Welcome!!!
  • 01/16 - First fish are in the facility swimming in their new Duck tanks!
  • 12/15 - Lab official started - here we go!